Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro.

@article{Kelleher2005HumanPO,
  title={Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro.},
  author={Colleen Kelleher and Isabel Kurth and Joachim Lingner},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 2},
  pages={808-18}
}
The telomeric single-strand DNA binding protein protection of telomeres 1 (POT1) protects telomeres from rapid degradation in Schizosaccharomyces pombe and has been implicated in positive and negative telomere length regulation in humans. Human POT1 appears to interact with telomeres both through direct binding to the 3' overhanging G-strand DNA and through interaction with the TRF1 duplex telomere DNA binding complex. The influence of POT1 on telomerase activity has not been studied at the… CONTINUE READING

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Biochemical aspects of telomerase function

  • L. Harrington
  • Cancer Lett. 194:139–154
  • 2003

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