Human prostate fibroblasts induce growth and confer castration resistance and metastatic potential in LNCaP Cells.

@article{Thalmann2010HumanPF,
  title={Human prostate fibroblasts induce growth and confer castration resistance and metastatic potential in LNCaP Cells.},
  author={George N Thalmann and Hong Jun Rhee and Robert A. Sikes and Sen Pathak and Ashi Multani and Haiyen E. Zhau and Fray F. Marshall and Leland W. K. Chung},
  journal={European urology},
  year={2010},
  volume={58 1},
  pages={162-71}
}
BACKGROUND The tumor microenvironment is important for progressive and metastatic disease. OBJECTIVE To study the hypothesis that prostate fibroblasts have differential ability to induce castration-resistant prostate cancer (PCa) and metastatic progression and whether this effect might vary depending on the zonal origin of the fibroblast. DESIGN, SETTING, AND PARTICIPANTS Human prostate fibroblasts from the peripheral (PZ), transition (TZ) and central (CZ) zones of radical prostatectomy… CONTINUE READING

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Human prostate fibroblasts induce growth and confer castration resistance and metastatic potential in LNCaP cells

GN Thalmann, H Rhee, RA Sikes
Eur Urol 2010;58:162–72 • 2010
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