Human prolactin responses to neuroleptic drugs correlate with antischizophrenic potency

@article{Langer1977HumanPR,
  title={Human prolactin responses to neuroleptic drugs correlate with antischizophrenic potency},
  author={G. Langer and E. Sachar and P. Gruen and F. Halpern},
  journal={Nature},
  year={1977},
  volume={266},
  pages={639-640}
}
THE secretion of prolactin, a pituitary hormone, is regulated by inhibitory and stimulatory influences from the hypothalamus. The primary influence is tonic inhibitory1. Dopamine, a neurotransmitter, has a major direct and/or indirect role in mediating this inhibition upon the prolactin cells in the pituitary gland. This is documented by studies in vitro1, in vivo2 and in man3. All known neuroleptic, antischizophrenic drugs share one characteristic—they block dopaminergic transmission4–7. This… Expand
Dopaminergic factors in human prolactin regulation: Effects of neuroleptics and dopamine
Drug-induced growth hormone and prolactin responses in schizophrenia research
  • S. Lal, N. Nair, +4 authors H. Guyda
  • Psychology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1982
Biochemical Effects (in Men)
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References

SHOWING 1-10 OF 11 REFERENCES
Dopamine-sensitive adenylate cyclase in mammalian brain: a possible site of action of antipsychotic drugs.
Effects of dopamine infusion on pituitary hormone secretion in humans.
Suppression of prolactin secretion by L-dopa in the stalk-sectioned rhesus monkey.
A radioimmunoassay for human prolactin.
  • P. Hwang, H. Guyda, H. Friesen
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1971
Chlorpromazine and dopamine: conformational similarities that correlate with the antischizophrenic activity of phenothiazine drugs.
  • A. Horn, S. Snyder
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1971
An anatomy of schizophrenia?
  • J. Stevens
  • Psychology, Medicine
  • Archives of general psychiatry
  • 1973
...
1
2
...