Human proinsulin C-peptide prevents proliferation of rat aortic smooth muscle cells cultured in high-glucose conditions

@article{Kobayashi2005HumanPC,
  title={Human proinsulin C-peptide prevents proliferation of rat aortic smooth muscle cells cultured in high-glucose conditions},
  author={Yosuke Kobayashi and Keiko Naruse and Yoji Hamada and Eitaro Nakashima and Kenichiro Kato and Nobuteru Akiyama and Hideki Kamiya and Atsuko Watarai and Mika Nakae and Yutaka Oiso and Jiro Nakamura},
  journal={Diabetologia},
  year={2005},
  volume={48},
  pages={2396-2401}
}
Proinsulin C-peptide is involved in several biological activities. However, the role of C-peptide in vascular smooth muscle cells is unclear. We therefore investigated its effects, in vascular smooth muscle cells in high-glucose conditions. Rat aortic smooth muscle cells were cultured with 5.5 or 20 mmol/l glucose with or without C-peptide (1 to 100 nmol/l) for 3 weeks. Proliferation activities, the protein expression of platelet-derived growth factor (PDGF)-beta receptor, the phosphorylation… CONTINUE READING