Human progesterone receptor polymorphisms and implantation failure during in vitro fertilization.

@article{Cramer2003HumanPR,
  title={Human progesterone receptor polymorphisms and implantation failure during in vitro fertilization.},
  author={Daniel W Cramer and Mark D. Hornstein and Patricia M McShane and R. Douglas Powers and Pamela Jean Lescault and Allison F. Vitonis and Immaculata de Vivo},
  journal={American journal of obstetrics and gynecology},
  year={2003},
  volume={189 4},
  pages={1085-92}
}
OBJECTIVE Polymorphic variants of the human progesterone receptor gene have been described, but their potential influence on in vitro fertilization outcome have not been studied. STUDY DESIGN DNA was available from 317 women (cases) who had >or=2 embryo transfers without a clinical pregnancy and from 288 women (control subjects) who became pregnant after 1 in vitro fertilization attempt. With protocols that were specific for H770H (C/T genotype) and +331G/A polymorphism, amplification of… CONTINUE READING