Human prion protein (PrP) 219K is converted to PrPSc but shows heterozygous inhibition in variant Creutzfeldt-Jakob disease infection.

Abstract

Prion protein gene (PRNP) E219K is a human polymorphism commonly occurring in Asian populations but is rarely found in patients with sporadic Creutzfeldt-Jakob disease (CJD). Thus the polymorphism E219K has been considered protective against sporadic CJD. The corresponding mouse prion protein (PrP) polymorphism variant (mouse PrP 218K) is not converted to… (More)
DOI: 10.1074/jbc.M809254200

Cite this paper

@article{Hizume2009HumanPP, title={Human prion protein (PrP) 219K is converted to PrPSc but shows heterozygous inhibition in variant Creutzfeldt-Jakob disease infection.}, author={Masaki Hizume and Atsushi Kobayashi and Kenta Teruya and Hiroaki Ohashi and James W Ironside and Shirou Mohri and Tetsuyuki Kitamoto}, journal={The Journal of biological chemistry}, year={2009}, volume={284 6}, pages={3603-9} }