Human prion diseases.

@article{Parchi1995HumanPD,
  title={Human prion diseases.},
  author={Plero Parchi and Pierluigi Gambetti},
  journal={The Medical clinics of North America},
  year={1995},
  volume={86 3},
  pages={551-71, vi-vii}
}
Major advances have been made in prion diseases. Recent data indicate that the prion protein is likely to be a synaptic protein with a functional role in synaptic transmission. An impressive body of evidence suggests that (1) the normal prion protein plays a central role in prion replication; (2) the replication process implies an interaction between the normal prion protein and the pathogenic prion protein; and (3) the pathogenic prion protein is the infectious agent, the infectivity of which… CONTINUE READING