Human primary ductal carcinoma in situ (DCIS) subtype-specific pathology is preserved in a mouse intraductal (MIND) xenograft model.

@article{Valdez2011HumanPD,
  title={Human primary ductal carcinoma in situ (DCIS) subtype-specific pathology is preserved in a mouse intraductal (MIND) xenograft model.},
  author={Kelli Elizabeth Valdez and Fang Fan and William Smith and Donald Craig Allred and Daniel J. Medina and Fariba Behbod},
  journal={The Journal of pathology},
  year={2011},
  volume={225 4},
  pages={565-73}
}
Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. The current recognition that DCIS lesions exhibit inter- and intra-lesion diversity suggests that the process of evolution to invasive breast cancer is more complex than previously recognized. Here we demonstrate the reproducible growth of primary DCIS cells derived from patient's surgical and biopsy samples by the mouse intraductal (MIND) model. MIND involves injection of cells into the NOD-SCID IL2Rgamma… CONTINUE READING
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