Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application.

@article{BergweltBaildon2002HumanPA,
  title={Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application.},
  author={Michael S. von Bergwelt-Baildon and Robert H. Vonderheide and Britta Maecker and Naoto Hirano and Karen S. Anderson and Marcus O Butler and Zhinan Xia and Wan Y Zeng and Kai W Wucherpfennig and Lee M. Nadler and Joachim L. Schultze},
  journal={Blood},
  year={2002},
  volume={99 9},
  pages={3319-25}
}
CD40 engagement is the major signal that induces B cells to efficiently present antigen to T cells. We previously demonstrated that human peripheral blood-derived CD40-activated B cells (CD40-B cells) function as antigen-presenting cells (APCs). Here, we have established a culture system to generate these APCs under clinically applicable conditions using guanylic acid-grade soluble trimeric CD40 ligand. To monitor APC function and antigen loading for these cells, simple and efficient quality… CONTINUE READING

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