Human pre-mRNA splicing signals.

  title={Human pre-mRNA splicing signals.},
  author={Fabio E. Penotti},
  journal={Journal of theoretical biology},
  volume={150 3},
A sample of 764 pairs of human pre-mRNA exon-intron and intron-exon boundaries, extracted from the European Molecular Biology Laboratory data bank, is analyzed to provide a species-optimized characterization of donor and acceptor sites, evaluate the information content of the two signals (found to be about 8 and 9 bits respectively) and check the independent-base approximation (which holds well) and the "GT-AG" rule (to which, a few well-documented exceptions are found). No correlation is… CONTINUE READING
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