Human polyhomeotic homolog 3 (PHC3) sterile alpha motif (SAM) linker allows open-ended polymerization of PHC3 SAM.

@article{Robinson2012HumanPH,
  title={Human polyhomeotic homolog 3 (PHC3) sterile alpha motif (SAM) linker allows open-ended polymerization of PHC3 SAM.},
  author={Angela K. Robinson and Belinda Z. Leal and David R. Nanyes and Yogeet Kaur and Udayar Ilangovan and Virgil R. Schirf and Andrew P. Hinck and Borries Demeler and Chongwoo A. Kim},
  journal={Biochemistry},
  year={2012},
  volume={51 27},
  pages={5379-86}
}
Sterile alpha motifs (SAMs) are frequently found in eukaryotic genomes. An intriguing property of many SAMs is their ability to self-associate, forming an open-ended polymer structure whose formation has been shown to be essential for the function of the protein. What remains largely unresolved is how polymerization is controlled. Previously, we had determined that the stretch of unstructured residues N-terminal to the SAM of a Drosophila protein called polyhomeotic (Ph), a member of the… CONTINUE READING