Human platelets exhibit chemotaxis using functional N-formyl peptide receptors.

@article{Czapiga2005HumanPE,
  title={Human platelets exhibit chemotaxis using functional N-formyl peptide receptors.},
  author={Meggan Czapiga and J Gao and Allan D. Kirk and Julie A Lekstrom-Himes},
  journal={Experimental hematology},
  year={2005},
  volume={33 1},
  pages={73-84}
}
OBJECTIVE Activated platelets participate in inflammatory and microbicidal processes by upregulation of surface selectins, shedding of CD40 ligand, and release of platelet microbicidal proteins and microparticles. Given their myeloid lineage, we hypothesized that platelets express functional N-formyl peptide receptors and respond to the bacterially derived chemotactic peptide N-formyl peptide with gradient-driven chemotaxis. METHODS AND RESULTS Here we show specific binding of N-formyl… CONTINUE READING

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: a communication link between innate and adaptive immune compartments

M Czapiga, A Kirk, JA Lekstrom-Himes
2003

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