Human platelet lysate stimulates high-passage and senescent human multipotent mesenchymal stromal cell growth and rejuvenation in vitro.

@article{Griffiths2013HumanPL,
  title={Human platelet lysate stimulates high-passage and senescent human multipotent mesenchymal stromal cell growth and rejuvenation in vitro.},
  author={Sarah Griffiths and Priya R. Baraniak and Ian B. Copland and Robert M. Nerem and Todd C. McDevitt},
  journal={Cytotherapy},
  year={2013},
  volume={15 12},
  pages={1469-83}
}
BACKGROUND AIMS Multipotent mesenchymal stromal cells (MSCs) are clinically useful because of their immunomodulatory and regenerative properties, but MSC therapies are limited by the loss of self-renewal and cell plasticity associated with ex vivo expansion culture and, on transplantation, increased immunogenicity from xenogen exposure during culture. Recently, pooled human platelet lysate (hPL) has been used as a culture supplement to promote MSC growth; however, the effects of hPL on MSCs… CONTINUE READING
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