Human platelet interaction with E. coli O111 promotes tissue-factor-dependent procoagulant activity, involving Toll like receptor 4

@inproceedings{Matus2017HumanPI,
  title={Human platelet interaction with E. coli O111 promotes tissue-factor-dependent procoagulant activity, involving Toll like receptor 4},
  author={Valeria Matus and J Guillermo Valenzuela and Patricia Hidalgo and Luz Mar{\'i}a Pozo and Olga Panes and Aniela Wozniak and Diego Mezzano and Jaime A Pereira and Claudia G. Saez},
  booktitle={PloS one},
  year={2017}
}
Platelets have a major role in clotting activation and contribute to the innate immune response during systemic infections. Human platelets contain tissue factor (TF) and express functional Toll-like receptor 4 (TLR4). However, the role of TLR4 in triggering the procoagulant properties of platelets, upon challenge with bacteria, is yet unknown. Our hypothesis is that E. coli O111-TLR4 interaction activates platelets and elicits their procoagulant activity. We demonstrated that the strain, but… CONTINUE READING
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