Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities.

@article{Tel2012HumanPD,
  title={Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities.},
  author={Jurjen Tel and Evelien Lj Smits and S{\'e}bastien A Anguille and Rubin N. Joshi and Carl G. Figdor and I Jolanda M de Vries},
  journal={Blood},
  year={2012},
  volume={120 19},
  pages={3936-44}
}
Human plasmacytoid dendritic cells (pDCs) represent a highly specialized naturally occurring dendritic-cell subset and are the main producers of type I interferons (IFNs) in response to viral infections. We show that human pDCs activated by the preventive vaccine FSME specifically up-regulate CD56 on their surface, a marker that was thought to be specific for NK cells and associated with cytolytic effector functions. We observed that FSME-activated pDCs specifically lysed NK target cells and… CONTINUE READING

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