Human plasma platelet-activating factor acetylhydrolase. Association with lipoprotein particles and role in the degradation of platelet-activating factor.

@article{Stafforini1987HumanPP,
  title={Human plasma platelet-activating factor acetylhydrolase. Association with lipoprotein particles and role in the degradation of platelet-activating factor.},
  author={Diana M. Stafforini and Thomas M McIntyre and Marian E. Carter and Stephen M. Prescott},
  journal={The Journal of biological chemistry},
  year={1987},
  volume={262 9},
  pages={4215-22}
}
Platelet-activating factor (PAF) is a bioactive phospholipid (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) synthesized by a variety of mammalian cell types. PAF induces hypotension, and activates neutrophils and platelets, among other actions. Removal of the acetyl moiety abolishes biological activity, so this reaction may regulate the concentration of PAF and its physiological effects. We have studied the significance of this reaction, which is catalyzed in vitro by an acetylhydrolase… CONTINUE READING
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