Human plasma membrane-derived vesicles halt proliferation and induce differentiation of THP-1 acute monocytic leukemia cells.

@article{AnsaAddo2010HumanPM,
  title={Human plasma membrane-derived vesicles halt proliferation and induce differentiation of THP-1 acute monocytic leukemia cells.},
  author={Ephraim A. Ansa-Addo and Sigrun Lange and D. H. Stratton and Samuel S. Antwi-Baffour and Igor Cestari and Marcel I. Ramirez and Maria V. McCrossan and Jameel M Inal},
  journal={Journal of immunology},
  year={2010},
  volume={185 9},
  pages={5236-46}
}
Plasma membrane-derived vesicles (PMVs) are small intact vesicles released from the cell surface that play a role in intercellular communication. We have examined the role of PMVs in the terminal differentiation of monocytes. The myeloid-differentiating agents all-trans retinoic acid/PMA and histamine, the inflammatory mediator that inhibits promonocyte proliferation, induced an intracellular Ca(2+)-mediated PMV (as opposed to exosome) release from THP-1 promonocytes. These PMVs cause THP-1… CONTINUE READING

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