Human plasma inhibitors of platelet serotonin uptake and imipramine receptor binding: extraction and heterogeneity.

Human plasma contains a considerable concentration of low molecular weight substances that inhibit, in a dose-dependent manner, both high-affinity imipramine receptor binding and serotonin uptake in platelets. Incubation of plasma with alumina was used to extract and to partly characterize these imipramine-like inhibitors. The human plasma extract inhibited… CONTINUE READING