Human plasma fluoride levels following intake of dentifrices containing aminefluoride or monofluorophosphate.

Abstract

After single, oral doses, 8 h profiles of fluoride (F) concentrations in plasma were determined in healthy human volunteers. Bioavailability of F from four dentifrices with either aminefluoride (AMF) or monofluorophosphate (MFP) was compared with that of NaF. There were no significant differences with respect to F availabilities, plasma F peak levels and plasma F profiles between NaF and the dentifrices tested, regardless of the F compound, F content or further ingredients. From the pharmacokinetic data it is concluded that dentifrices with 0.02 per cent F or less markedly decrease the risk of inducing plasma F concentrations that might disturb enamel mineralization, even if large quantities of dentifrice are ingested by small children.

Cite this paper

@article{Trautner1988HumanPF, title={Human plasma fluoride levels following intake of dentifrices containing aminefluoride or monofluorophosphate.}, author={Katharina Trautner and Johannes Einwag}, journal={Archives of oral biology}, year={1988}, volume={33 8}, pages={543-6} }