Human plasma adenosine deaminase 2 is secreted by activated monocytes.

@article{IwakiEgawa2006HumanPA,
  title={Human plasma adenosine deaminase 2 is secreted by activated monocytes.},
  author={Sachiko Iwaki-Egawa and Takaya Yamamoto and Yasuhiro Watanabe},
  journal={Biological chemistry},
  year={2006},
  volume={387 3},
  pages={319-21}
}
Adenosine deaminase (ADA) plays an important role in the immune system, and its activity is composed of two kinetically distinct isozymes, ADA1 and ADA2. ADA2 is a major component of human plasma total ADA activity and ADA2 activity is significantly elevated in patients with various diseases such as HIV infection and chronic hepatitis. However, relatively little is known about ADA2 because of difficulties in purifying this enzyme. In this study we succeeded in purifying human plasma ADA2 and… CONTINUE READING