Human placental peroxisome proliferator-activated receptor delta and gamma expression in healthy pregnancy and in preeclampsia and intrauterine growth restriction.

@article{Rodie2005HumanPP,
  title={Human placental peroxisome proliferator-activated receptor delta and gamma expression in healthy pregnancy and in preeclampsia and intrauterine growth restriction.},
  author={Vanessa A. Rodie and Anne Mary Young and Fiona Jordan and Naveed 4 Sattar and Ian Andrew Greer and Dilys Jane Freeman},
  journal={Journal of the Society for Gynecologic Investigation},
  year={2005},
  volume={12 5},
  pages={320-9}
}
OBJECTIVES Human and animal studies have demonstrated that peroxisome proliferator-activated receptors (PPARs) are important in placental development and play key roles in metabolism and inflammation. We studied placental PPARdelta, PPARgamma, and retinoid X receptor alpha (RXRalpha) expression in healthy pregnancy and in preeclampsia (PET) and intrauterine growth restriction (IUGR). METHODS AND RESULTS Using immunocytochemistry, PPARdelta, PPARgamma, and RXRalpha were localized to the cyto… CONTINUE READING