Human placental metabolic adaptation to chronic hypoxia, high altitude: hypoxic preconditioning

@inproceedings{Patot2010HumanPM,
  title={Human placental metabolic adaptation to chronic hypoxia, high altitude: hypoxic preconditioning},
  author={Martha C. Tissot van Patot and Andrew James Murray and Virginia E Beckey and Tereza Cindrova-Davies and Jemma Johns and Lisa Zwerdlinger and Eric Jauniaux and Graham J Burton and Natalie J. Serkova},
  booktitle={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2010}
}
We have previously demonstrated placentas from laboring deliveries at high altitude have lower binding of hypoxia-inducible transcription factor (HIF) to DNA than those from low altitude. It has recently been reported that labor causes oxidative stress in placentas, likely due to ischemic hypoxic insult. We hypothesized that placentas of high-altitude residents acquired resistance, in the course of their development, to oxidative stress during labor. Full-thickness placental tissue biopsies… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Similar Papers

Loading similar papers…