Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle.

@article{Barbour2004HumanPG,
  title={Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle.},
  author={Linda A Barbour and Jianhua Shao and Liping Qiao and Wayne Leitner and Marianne S Anderson and Jacob E. Friedman and Boris B Draznin},
  journal={Endocrinology},
  year={2004},
  volume={145 3},
  pages={1144-50}
}
The insulin resistance of normal pregnancy is necessary to divert fuels to the fetus to meet fetal growth demands and is mediated by placental hormones. We recently demonstrated that human placental GH (hPGH) can trigger severe insulin resistance in transgenic (TG) mice. In this study we sought to elucidate the cellular mechanisms by which hPGH interferes with insulin signaling in muscle in TG mice. Insulin-stimulated GLUT-4 translocation to the plasma membrane (PM) was reduced in the TG… CONTINUE READING

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