Human placental extract stimulates liver regeneration in rats.

  title={Human placental extract stimulates liver regeneration in rats.},
  author={Kexin Liu and Yasuki Kato and Tomohiro Kaku and Yuichi Sugiyama},
  journal={Biological & pharmaceutical bulletin},
  volume={21 1},
The effect of human placental extract (HPE) on liver regeneration in rats was investigated. After intravenous administration of HPE to a-naphthylisothiocyanate (ANIT)-intoxicated rats, the labeling index in hepatocytes was significantly increased to a level 16.5 times higher than that of the control. A 1/500 dilution of HPE directly stimulated DNA synthesis of the hepatocytes in primary culture. HPE heated at 121 degrees C did not stimulate the labeling index in vivo or hepatocyte DNA synthesis… CONTINUE READING


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Clinical Pharmacol Ther

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