Human placental ectonucleoside triphosphate diphosphohydrolase gene transfer via gelatin-coated stents prevents in-stent thrombosis.

@article{Takemoto2009HumanPE,
  title={Human placental ectonucleoside triphosphate diphosphohydrolase gene transfer via gelatin-coated stents prevents in-stent thrombosis.},
  author={Yasuhiro Takemoto and Hiroyuki Kawata and Tsunenari Soeda and Keiichi Imagawa and Satoshi Somekawa and Yukiji Takeda and Shiro Uemura and Masanori Matsumoto and Yoshihiro Fujimura and Jun-ichiro Jo and Yu Kimura and Yasuhiko Tabata and Yoshihiko Saito},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2009},
  volume={29 6},
  pages={857-62}
}
BACKGROUND In-stent thrombosis is mainly triggered by adenosine diphosphate (ADP)-dependent platelet aggregation after percutaneous coronary stent implantation. Ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) rapidly hydrolyzes ADP to adenosine monophosphate, inhibiting platelet aggregation. We tested the hypothesis that local delivery of human… CONTINUE READING