Human placental development is impaired by abnormal human chorionic gonadotropin signaling in trisomy 21 pregnancies.

@article{Pidoux2007HumanPD,
  title={Human placental development is impaired by abnormal human chorionic gonadotropin signaling in trisomy 21 pregnancies.},
  author={Guillaume Pidoux and Pascale Gerbaud and Olivier Marpeau and Jean Guibourdenche and F{\'a}tima Regina Ferreira and Josette Badet and Dani{\`e}le Evain-Brion and Jean-Louis Frendo},
  journal={Endocrinology},
  year={2007},
  volume={148 11},
  pages={5403-13}
}
Placental development is markedly abnormal in women bearing a fetus with trisomy 21, with defective syncytiotrophoblast (ST) formation and function. The ST occurs from cytotrophoblast (CT) fusion and plays an essential role by secreting human chorionic gonadotropin (hCG), which is essential to placental development. In trisomy of chromosome 21 (T21) pregnancies, CTs do not fuse and differentiate properly into STs, leading to the secretion of an abnormal and weakly bioactive hCG. In this study… CONTINUE READING
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