Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma gene locus.

@article{Zhu1994HumanPA,
  title={Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma gene locus.},
  author={J J Zhu and Steven P. Leon and Alan H. Beggs and Lambert Busque and D. Gary Gilliland and P M Black},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1994},
  volume={78 4},
  pages={
          922-7
        }
}
  • J. Zhu, S. Leon, +3 authors P. Black
  • Published 1 April 1994
  • Biology, Medicine
  • The Journal of clinical endocrinology and metabolism
The retinoblastoma tumor suppressor gene (RB1) is inactivated in hereditary and sporadic forms of retinoblastoma as well as in a number of other sporadic tumors. The majority of human pituitary tumors have been shown to be monoclonal neoplasms, suggesting that 1 or more somatic mutations are involved in the clonal expansion of a single progenitor cell. Recently, a high percentage of transgenic mice containing a disrupted RB1 allele have been shown to develop pituitary tumors. To investigate… 
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Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumor suppressor gene other than RB.
TLDR
Although inactivation of RB may play a role in the development of invasive pituitary adenomas and carcinomas in mice, another tumor suppressor gene on 13q is likely involved in human pituitsary tumor progression.
Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas
TLDR
LOH at 11q13 and 13q may be valuable in predicting the invasiveness of pituitary adenomas and no mutation or overexpression of p53 was found, but no homozygous deletions of p15 or p16 were identified.
Mutations of the MEN1 tumor suppressor gene in pituitary tumors.
TLDR
The data suggest that somatic MEN1 gene mutations and deletions play a causative role in the development of a subgroup of sporadic pituitary adenomas.
Mutations of the MEN1 tumor suppressor gene in sporadic pituitary tumors.
Human pituitary adenomas infrequently contain inactivation of retinoblastoma 1 gene and activation of cyclin dependent kinase 4 gene.
TLDR
It is concluded that somatic mutations of the RB1 gene or CDK4 gene do not appear to play a major role in pituitary tumorigenesis and supports the presence of potential tumor suppressor gene(s) on 13q12.3-q13 to 13q31-32 in pituitsary adenomas.
Allelic Loss in Pituitary Tumors in Patients with Multiple Endocrine Neoplasia Syndrome Type 1
TLDR
The number of different inactivating mutations in the MEN 1 gene and evidence for loss of the wild-type allele in different tumor types in MEN I patients suggest that the MEN I gene functions as a tumor suppressor gene, consistent with Knudson’s two-hit model.
11q13 allelic loss in pituitary tumors in patients with multiple endocrine neoplasia syndrome type 1.
  • R. Weil, A. Vortmeyer, +6 authors E. Oldfield
  • Medicine, Biology
    Clinical cancer research : an official journal of the American Association for Cancer Research
  • 1998
TLDR
Genetic alterations of the MEN 1 gene seem to play a dominant role in MEN 1-associated pituitary tumorigenesis, whereas gsp gene mutations do not seem to be a frequent event in either growth hormone-secreting or other types of MEN 2-associatedpituitary tumors.
Detection of heterozygous mutation in the retinoblastoma gene in a human pituitary adenoma using PCR-SSCP analysis and direct sequencing
TLDR
It is suggested that point mutation of retinoblastoma gene is rare in human pituitary adenomas but may provide a marker for aggressive pituitARY adenoma.
Tumor Suppressor Loss in Pituitary Tumors
TLDR
Despite insights into pituitary tumorigenesis generated by heritable neoplasia syndromes and mouse knockout of critical TSGs that display a pituitsary tumor phenotype, the molecular pathogenesis of human pituitaries adenomas remains largely an enigma.
Allelic deletion in pituitary adenomas reflects aggressive biological activity and has potential value as a prognostic marker.
TLDR
Testing the hypothesis that genetic deletions are a marker of invasive behavior and identifying the loci most commonly involved in invasive tumors found a breakpoint between markers intragenic and extragenic to the retinoblastoma gene (Rb1) on chromosome 13q, suggesting that tumor suppressor genes other than or in addition to Rb1 may be involved in pituitary tumorigenesis.
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References

SHOWING 1-10 OF 36 REFERENCES
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TLDR
It is indicated that the retinoblastoma (RB) gene inactivation probably does not play an important role in the pathogenesis of common types of human pituitary tumors.
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TLDR
Analysis of the variable number of tandem repeat sequence polymorphism in intron 20 in the RB gene revealed that 6 (30%) of 20 patients with informative samples showed allelic loss at the RB locus in their tumor tissues, which suggests that the RB genes, or a closely linked gene, seems to be involved in the development of ovarian cancer.
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  • Biology, Medicine
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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