Human pineal physiology and functional significance of melatonin

@article{Macchi2004HumanPP,
  title={Human pineal physiology and functional significance of melatonin},
  author={M. Mila Macchi and Jeffrey N. Bruce},
  journal={Frontiers in Neuroendocrinology},
  year={2004},
  volume={25},
  pages={177-195}
}
Descriptions of the pineal gland date back to antiquity, but its functions in humans are still poorly understood. In both diurnal and nocturnal vertebrates, its main product, the hormone melatonin, is synthesized and released in rhythmic fashion, during the dark portion of the day-night cycle. Melatonin production is controlled by an endogenous circadian timing system and is also suppressed by light. In lower vertebrates, the pineal gland is photosensitive, and is the site of a self-sustaining… Expand
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