Human photosensitivity: from pathophysiology to treatment

  title={Human photosensitivity: from pathophysiology to treatment},
  author={Alberto Verrotti and Anna Maria Tocco and Carmela Salladini and Giuseppe Latini and Francesco Chiarelli},
  journal={European Journal of Neurology},
Photosensitivity is a condition detected on the electroencephalography (EEG) as a paroxysmal reaction to Intermittent Photic Stimulation (IPS). This EEG response, elicited by IPS or by other visual stimuli of daily life, is called Photo Paroxysmal Response (PPR). PPRs are well documented in epileptic and non‐epileptic subjects. Photosensitivity rarely in normal individuals evolves into epilepsy. Photosensitive epilepsy is a rare refex epilepsy characterized by seizures in photosensitive… 

Photosensitivity: epidemiology, genetics, clinical manifestations, assessment, and management

This review focuses on the emerging aspects of photosensitivity, in particular, the new guidelines for intermittent photic stimulation and briefly addresses epidemiological (in non-epileptic and epileptic subjects), genetic, diagnostic, and therapeutic issues.

Effects of clonazepam on self-induced photoparoxysmal responses

Clinical and EEG Analysis of Patients With Idiopathic Generalized Epilepsy and Photosensitivity

The findings in a retrospective cohort suggest that having AS is a negative prognostic factor for the seizure outcome in patients with photosensitive IGE.

Exposure to Intermittent Light During EEG to Support the Diagnosis of Seizure Conditions inPatients at Children

Evaluation of using PST in EEG in patients diagnosed because of paroxysmal conditions finds that in some children PST is the only technique which makes it possible to recognize a photogenic epilepsy (pure one).

Relationship Between Fatigue and Photosensitivity

Fatigue is associated with photosensitivity, and new perspectives on fatigue are provided.

Photoparoxysmal responses in children with chromosomal aberrations

Investigation of the Relationship Between Clinical and EEG Findings of Photosensitive Epilepsy and GABA Receptor Alpha 1 Subunit (GABRA1) Gene Mutations

The lack of mutations in the GABRA1 gene indicates that this gene is not predominantly involved in the etiopathogenesis of PE in the Turkish population, and the research should be extended by increasing the number of patients and by investigating other genes related to GABA.



Role of Dopamine in Generalized Photosensitive Epilepsy: Electroencephalographic and Biochemical Aspects

The EEG hallmark of epileptic photosensitivity is the photoconvulsive response, consisting of bursts of generalized and bilaterally synchronous spike-and-wave or polyspike- and-wave activity induced by photic stimulation.

Clinical Significance of EEG Abnormalities During Photic Stimulation in Patients with Photosensitive Epilepsy

Those EEG abnormalities that may be tolerated with low risk of further seizures, and those that are indicative of poor seizure control are described.

Photosensitive partial seizure: The origin of abnormal discharges

Photosensitivity in epilepsy. Electrophysiological and clinical correlates.

This thesis describes the results of an extensive and standardized study of 100 consecutive photosensitive patients with special emphasis on the clinical history, the seizure history and the electrophysiological findings.

Physiology of Human Photosensitivity

The topographic distribution of epileptiform EEG activity in response to such stimuli has complemented this approach, leading to the inference that the trigger is cortical and requires sychronised mass action of neurons.

Photosensitivity: genetics and clinical significance.

The available data provide evidence for autosomal dominant inheritance of photosensitivity, and the phenomenon could be shown to be a widespread condition being only loosely associated with epilepsy, but more often with symptoms of psychovegetative instability.

The clinical significance of occipital spikes as a sole response to intermittent photic stimulation.

  • M. Maheshwari
  • Medicine
    Electroencephalography and clinical neurophysiology
  • 1975

Photosensitive Epilepsy

Photosensitive epilepsy (PE) is the most frequent form of reflex epilepsy and Authors picked out two PE forms based on the analysis of the 16 own observations -with self-induction of the fits.

Occipital spikes and their relation to visual responses in epilepsy, with particular reference to photosensitive epilepsy.

Photosensitivity: a vestigial echo? The first Grey Walter Lecture.

  • G. Harding
  • Biology, Medicine
    International journal of psychophysiology : official journal of the International Organization of Psychophysiology
  • 1994