Human photoreceptor outer segments shorten during light adaptation.

@article{Abrmoff2013HumanPO,
  title={Human photoreceptor outer segments shorten during light adaptation.},
  author={Michael D. Abr{\`a}moff and Robert F. Mullins and Kyungmoo Lee and Jeremy M Hoffmann and Milan Sonka and Douglas B Critser and Steven F. Stasheff and Edwin M. Stone},
  journal={Investigative ophthalmology & visual science},
  year={2013},
  volume={54 5},
  pages={3721-8}
}
PURPOSE Best disease is a macular dystrophy caused by mutations in the BEST1 gene. Affected individuals exhibit a reduced electro-oculographic (EOG) response to changes in light exposure and have significantly longer outer segments (OS) than age-matched controls. The purpose of this study was to investigate the anatomical changes in the outer retina during dark and light adaptation in unaffected and Best disease subjects, and to compare these changes to the EOG. METHODS Unaffected (n = 11… CONTINUE READING