Human pharmacology and abuse potential of the analgesic buprenorphine: a potential agent for treating narcotic addiction.

@article{Jasinski1978HumanPA,
  title={Human pharmacology and abuse potential of the analgesic buprenorphine: a potential agent for treating narcotic addiction.},
  author={D. Jasinski and J. Pevnick and J. D. Griffith},
  journal={Archives of general psychiatry},
  year={1978},
  volume={35 4},
  pages={
          501-16
        }
}
  • D. Jasinski, J. Pevnick, J. D. Griffith
  • Published 1978
  • Psychology, Medicine
  • Archives of general psychiatry
  • Buprenorphine was evaluated for its abuse potential and utility in treating narcotic addiction. The drug was morphine-like but was 25 to 50 times more potent than morphine and was longer-acting. Little if any physical dependence of clinical significance was produced by buprenorphine. The effects of morphine to 120-mg doses were blocked by buprenorphine, a blockade that persisted for 29 1/2 hours. In man, buprenorphine has less intrinsic activity than morphine, and as such, as a low abuse… CONTINUE READING
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