Human pharmacokinetic study of heated intraperitoneal oxaliplatin in increasingly hypotonic solutions after complete resection of peritoneal carcinomatosis.

@article{Elias2002HumanPS,
  title={Human pharmacokinetic study of heated intraperitoneal oxaliplatin in increasingly hypotonic solutions after complete resection of peritoneal carcinomatosis.},
  author={Dominique M Elias and Azzedine El Otmany and Marc M. Bonnay and Angelo Paci and Michel Ducreux and Sami Antoun and Philippe Lasser and St{\'e}phane Laurent and Philippe Bourget},
  journal={Oncology},
  year={2002},
  volume={63 4},
  pages={346-52}
}
PURPOSE We studied the pharmacokinetics of heated intraoperative intraperitoneal (i.p.) oxaliplatin (LOHP) solution and its safety profile in increasingly hypotonic solutions. This is the first clinical study of i.p. chemohyperthermia with hypotonic solutions. METHODS Patients with peritoneal carcinomatosis (PC) underwent complete cytoreductive surgery followed by intraoperative i.p. chemohyperthermia (IPCH) with successive dextrose solutions of 300, 200, 150 and 100 mosm/l. LOHP (460 mg/m(2… CONTINUE READING
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