Human peroxisome proliferator-activated receptor alpha (PPARalpha) supports the induction of peroxisome proliferation in PPARalpha-deficient mouse liver.

@article{Yu2001HumanPP,
  title={Human peroxisome proliferator-activated receptor alpha (PPARalpha) supports the induction of peroxisome proliferation in PPARalpha-deficient mouse liver.},
  author={Songtao Yu and W. Q. Cao and Papreddy V Kashireddy and Kirstin Meyer and Yuzhi Jia and Douglas E. Hughes and Yongjun Tan and Jianchi Feng and Anjana V. Yeldandi and M. Sambasiva Rao and Robert H. Costa and Frank J. Gonzalez and Janardan K. Reddy},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 45},
  pages={42485-91}
}
Peroxisome proliferators, which function as peroxisome proliferator-activated receptor alpha (PPARalpha) agonists, induce peroxisomal, microsomal, and mitochondrial fatty acid oxidation enzymes, in conjunction with peroxisome proliferation, in liver cells. Sustained activation of PPARalpha leads to the development of liver tumors in rats and mice. The assertion that synthetic PPARalpha ligands pose negligible carcinogenic risk to humans is attributable, in part, to the failure to observe… CONTINUE READING

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