Human peripheral blood mononuclear cells (PBMCs) from smokers release higher levels of IL-1-like cytokines after exposure to combustion-generated ultrafine particles

@inproceedings{Falco2017HumanPB,
  title={Human peripheral blood mononuclear cells (PBMCs) from smokers release higher levels of IL-1-like cytokines after exposure to combustion-generated ultrafine particles},
  author={Gianluigi De Falco and Michela Terlizzi and Mariano Sirignano and Mario Commodo and Andrea D’Anna and Rita Patrizia Aquino and Aldo Pinto and Rosalinda Sorrentino},
  booktitle={Scientific reports},
  year={2017}
}
Ultrafine particles (UFP) generated by combustion processes are often associated with adverse health effects. However, little is known about the inflammatory processes generated by UFP that may underlie their toxicological activity. Murine macrophages (J774.1 cells) and human peripheral blood mononuclear cells (PBMCs) were used to evaluate the molecular mechanism underlying the pro-inflammatory activity of UFP. The addition of soot particles to J774.1 cells induced a concentration-dependent… CONTINUE READING