Human peripheral blood-derived dendritic cells express functional melanocortin receptor MC-1R.

@article{Becher1999HumanPB,
  title={Human peripheral blood-derived dendritic cells express functional melanocortin receptor MC-1R.},
  author={Eva Becher and Karsten Mahnke and Thomas Brzoska and D H Kalden and Stephan Grabbe and Thomas Anton Luger},
  journal={Annals of the New York Academy of Sciences},
  year={1999},
  volume={885},
  pages={188-95}
}
The neuropeptide, alpha-melanocyte-stimulating hormone (alpha-MSH) is well known for its immunomodulating capabilities. alpha-MSH antagonizes the activity of numerous proinflammatory mediators; for example, Interleukin-1 (IL-1), IL-6, tumor necrosis factor alpha (TNF alpha), and bacterial endotoxin. In vivo alpha-MSH has been shown to suppress a contact hypersensitivity reaction in mice, and to induce hapten-specific tolerance. Since antigen presenting cells (APC) represent key elements for… CONTINUE READING