Human peripheral blood T regulatory cells (Tregs), functionally primed CCR4+ Tregs and unprimed CCR4- Tregs, regulate effector T cells using FasL.

@article{Baatar2007HumanPB,
  title={Human peripheral blood T regulatory cells (Tregs), functionally primed CCR4+ Tregs and unprimed CCR4- Tregs, regulate effector T cells using FasL.},
  author={Dolgor Baatar and Purevdorj B. Olkhanud and Kenya Sumitomo and Dennis Taub and Ronald Gress and Arya Biragyn},
  journal={Journal of immunology},
  year={2007},
  volume={178 8},
  pages={4891-900}
}
Regulatory CD25(+)CD4(+) T cells (Tregs) play an important role in the control of peripheral tolerance. In this study we demonstrate that human peripheral blood Tregs can be divided into two distinct populations based on the expression of CCR4. The majority ( approximately 75%) of freshly isolated Tregs express CCR4 and presumably represent memory-type Tregs. Interestingly, CCR4(-) Tregs require anti-CD3 Ab-mediated activation to acquire a regulatory activity, while CCR4(+) Tregs appear to be… CONTINUE READING

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