Human pericytes for ischemic heart repair.

  title={Human pericytes for ischemic heart repair.},
  author={Chien-Wen Chen and Masaho Okada and Jonathan D. Proto and Xueqin Gao and Naosumi Sekiya and Sarah A. Beckman and Mirko Corselli and Mihaela Crisan and Arman Saparov and Kimimasa Tobita and Bruno P{\'e}ault and Johnny Huard},
  journal={Stem cells},
  volume={31 2},
Human microvascular pericytes (CD146(+)/34(-)/45(-)/56(-)) contain multipotent precursors and repair/regenerate defective tissues, notably skeletal muscle. However, their ability to repair the ischemic heart remains unknown. We investigated the therapeutic potential of human pericytes, purified from skeletal muscle, for treating ischemic heart disease and mediating associated repair mechanisms in mice. Echocardiography revealed that pericyte transplantation attenuated left ventricular… CONTINUE READING
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