Human pericytes adopt myofibroblast properties in the microenvironment of the IPF lung.

@article{Sava2017HumanPA,
  title={Human pericytes adopt myofibroblast properties in the microenvironment of the IPF lung.},
  author={Parid Sava and Anand Ramanathan and Amelia Dobronyi and Xueyan Peng and Huanxing Sun and Adrian Ledesma-Mendoza and Erica L. Herzog and Anjelica L Gonzalez},
  journal={JCI insight},
  year={2017},
  volume={2 24}
}
Idiopathic pulmonary fibrosis (IPF) is a fatal disease of unknown etiology characterized by a compositionally and mechanically altered extracellular matrix. Poor understanding of the origin of α-smooth muscle actin (α-SMA) expressing myofibroblasts has hindered curative therapies. Though proposed as a source of myofibroblasts in mammalian tissues, identification of microvascular pericytes (PC) as contributors to α-SMA-expressing populations in human IPF and the mechanisms driving this… CONTINUE READING