Human parvovirus B19 non-structural protein (NS1) induces apoptosis through mitochondria cell death pathway in COS-7 cells.

@article{Hsu2004HumanPB,
  title={Human parvovirus B19 non-structural protein (NS1) induces apoptosis through mitochondria cell death pathway in COS-7 cells.},
  author={Tsai-Ching Hsu and Wen-jun Wu and M Chen and Gregory Jiazer Tsay},
  journal={Scandinavian journal of infectious diseases},
  year={2004},
  volume={36 8},
  pages={570-7}
}
Human parvovirus B19 has been found in various tissues in addition to erythroid lineage cells, and non-structural protein (NS1) is reported to induce cytotoxicity and apoptosis in erythroid lineage cells, but the mechanism in non-permissive cells is still unclear. To address this issue, we have constructed the NS1 gene in a cytomegalovirus episomal vector, pEGFP-C1 and transfected it into monkey epithelial cells, COS-7. EGFP-NS1 expression in transfected cells was monitored and assessed by… CONTINUE READING
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