Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors.

@article{Wan2010HumanPB,
  title={Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors.},
  author={Zhihong Wan and Ning Zhi and Susan Wong and Keyvan Keyvanfar and Delong Liu and Nalini Raghavachari and Peter J. Munson and Su Su and Daniela Malide and Sachiko Kajigaya and Neal S. Young},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 10},
  pages={3530-44}
}
Human parvovirus B19 (B19V) is the only human pathogenic parvovirus. It causes a wide spectrum of human diseases, including fifth disease (erythema infectiosum) in children and pure red cell aplasia in immunocompromised patients. B19V is highly erythrotropic and preferentially replicates in erythroid progenitor cells (EPCs). Current understanding of how B19V interacts with cellular factors to regulate disease progression is limited, due to a lack of permissive cell lines and animal models. Here… CONTINUE READING
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