Human parotid saliva contains soluble toll-like receptor (TLR) 2 and modulates TLR2-mediated interleukin-8 production by monocytic cells.

@article{Kuroishi2007HumanPS,
  title={Human parotid saliva contains soluble toll-like receptor (TLR) 2 and modulates TLR2-mediated interleukin-8 production by monocytic cells.},
  author={T Kuroishi and Yukinori Tanaka and Azusa Sakai and Yumiko Sugawara and Ken-Ichi Komine and Shunji Sugawara},
  journal={Molecular immunology},
  year={2007},
  volume={44 8},
  pages={1969-76}
}
Toll-like receptor (TLR) family members are pattern-recognition receptors and very important molecules in innate immunity. Although TLRs are originally type I transmembrane receptors, soluble forms of TLRs are detected in human plasma and milk. This study showed that soluble TLR2 (sTLR2) is detected in human parotid saliva. Western blotting with anti-TLR2 antibodies (Abs) showed that three polypeptides are detected as sTLR2 with molecular weights of 55, 40 and 27kDa, respectively. Parotid… CONTINUE READING

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