Human papillomaviruses modulate microRNA 145 expression to directly control genome amplification.

@article{Gunasekharan2013HumanPM,
  title={Human papillomaviruses modulate microRNA 145 expression to directly control genome amplification.},
  author={Vignesh Kumar Gunasekharan and Laimonis Laimins},
  journal={Journal of virology},
  year={2013},
  volume={87 10},
  pages={6037-43}
}
Human papillomaviruses (HPVs) modulate expression of host microRNAs. Our deep-sequencing analysis of organotypic raft cultures identified microRNA 145 (miR-145) as a differentiation-dependent microRNA that has functionally active target sequences in the HPV-31 E1 and E2 open reading frames. Overexpression of miR-145 in HPV-positive cells resulted in reduced… CONTINUE READING