Human papillomavirus type 59 immortalized keratinocytes express late viral proteins and infectious virus after calcium stimulation.

@article{Lehr2003HumanPT,
  title={Human papillomavirus type 59 immortalized keratinocytes express late viral proteins and infectious virus after calcium stimulation.},
  author={Elizabeth E. Lehr and Brahim Qadadri and Carolanne R. Brown and Darron R. Brown},
  journal={Virology},
  year={2003},
  volume={314 2},
  pages={
          562-71
        }
}
Human papillomavirus type 59 (HPV 59) is an oncogenic type related to HPV 18. HPV 59 was recently propagated in the athymic mouse xenograft system. A continuous keratinocyte cell line infected with HPV 59 was created from a foreskin xenograft grown in an athymic mouse. Cells were cultured beyond passage 50. The cells were highly pleomorphic, containing numerous abnormally shaped nuclei and mitotic figures. HPV 59 sequences were detected in the cells by DNA in situ hybridization in a diffuse… CONTINUE READING
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