• Corpus ID: 45584342

Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites.

  title={Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites.},
  author={Erik C. Thorland and Shannon L. Myers and David H. Persing and Gobinda Sarkar and Renee M. McGovern and Bobbie S. Gostout and D. Smith},
  journal={Cancer research},
  volume={60 21},
The development of cervical cancer is highly associated with human papillomavirus (HPV) infection. HPV integration into the genome of infected cervical cells is temporally associated with the acquisition of the malignant phenotype. A relationship between the sites of HPV integration in cervical cancer and the position of the common fragile sites (CFSs) has been observed at the cytogenetic level. To explore this relationship at the molecular level, we used a PCR-based method to rapidly isolate… 

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Preferential sites for the integration and disruption of human papillomavirus 16 in cervical lesions.

  • Hui LiYi Yang B. Zhu
  • Biology, Medicine
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2013

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Allelotyping of all chromosomal arms in invasive cervical cancer.

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Analysis of integrated human papillomavirus type 16 DNA in cervical cancers: amplification of viral sequences together with cellular flanking sequences

It was demonstrated that the integrated HPV-16 DNAs, with different sizes in the same specimens, shared the same cellular flanking sequences at the ends, and it was shown that the viral sequences together with cellular flanks sequences were amplified.

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Molecular analysis of cellular loci disrupted by papillomavirus 16 integration in cervical cancer: Frequent viral integration in topologically destabilized and transcriptionally active chromosomal regions

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FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites.

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