• Corpus ID: 45584342

Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites.

@article{Thorland2000HumanPT,
  title={Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites.},
  author={Erik C. Thorland and Shannon L. Myers and David H. Persing and Gobinda Sarkar and Renee M. McGovern and Bobbie S. Gostout and D. Smith},
  journal={Cancer research},
  year={2000},
  volume={60 21},
  pages={
          5916-21
        }
}
The development of cervical cancer is highly associated with human papillomavirus (HPV) infection. HPV integration into the genome of infected cervical cells is temporally associated with the acquisition of the malignant phenotype. A relationship between the sites of HPV integration in cervical cancer and the position of the common fragile sites (CFSs) has been observed at the cytogenetic level. To explore this relationship at the molecular level, we used a PCR-based method to rapidly isolate… 
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Preferential sites for the integration and disruption of human papillomavirus 16 in cervical lesions.

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  • Biology, Medicine
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2013

Identification of human papillomavirus type 16 integration sites in high-grade precancerous cervical lesions.

Multiplex Identification of Human Papillomavirus 16 DNA Integration Sites in Cervical Carcinomas

A novel multiplex strategy for sequence determination of HPV16 DNA integration sites worked very efficiently and will open new avenues for comprehensive mapping of HPV integration sites and for the possible use of HPV Integration sites as individualized biomarkers after cancer treatment of patients for the early diagnosis of residual and recurrent disease.

The majority of viral-cellular fusion transcripts in cervical carcinomas cotranscribe cellular sequences of known or predicted genes.

The influence of HPV integration on host gene expression may not be a rare effect and should encourage more detailed analyses, as it is tempting to speculate that as yet unknown fragile sites may be identified on the basis of HPV Integration hotspots.

Simultaneous mapping of human papillomavirus integration sites and molecular karyotyping in short-term cultures of cervical carcinomas by using 49-color combined binary ratio labeling fluorescence in situ hybridization.

Mapping and analysis of HPV16 integration sites in a head and neck cancer cell line

The results suggest that viral integration of HPV in SCCHN appears to occur nonrandomly through targeting specific chromosomal sequences prone to breakage.

Positioning of cervical carcinoma and Burkitt lymphoma translocation breakpoints with respect to the human papillomavirus integration cluster in FRA8C at 8q24.13.

Human Papillomavirus Integration Strictly Correlates with Global Genome Instability in Head and Neck Cancer

The results indicate that HPV integration in head and neck cancer correlates with extensive pangenomic structural variation, which may have prognostic implications and suggests that HPV Integration status may inform prognosis.

Human papilloma viruses and cervical tumours: mapping of integration sites and analysis of adjacent cellular sequences

Using the known locations of homologous cDNAs and the RH-mapping techniques, mapping studies showed that the INTs are distributed among different human chromosomes for each tumour sample and are located in regions with the high levels of expression.

Systematic Review of Genomic Integration Sites of Human Papillomavirus Genomes in Epithelial Dysplasia and Invasive Cancer of the Female Lower Genital Tract

It is confirmed that HPV integration sites are randomly distributed over the whole genome with a clear predilection for genomic fragile sites, and no evidence for targeted disruption or functional alteration of critical cellular genes by the integrated viral sequences could be found.
...

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