Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase.

@article{Kao2000HumanPT,
  title={Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase.},
  author={Wynn H. Kao and Sylvie L. Beaudenon and Anna Talis and Jon M. Huibregtse and Peter M Howley},
  journal={Journal of virology},
  year={2000},
  volume={74 14},
  pages={6408-17}
}
The E6 protein of the high-risk human papillomaviruses (HPVs) and the cellular ubiquitin-protein ligase E6AP form a complex which causes the ubiquitination and degradation of p53. We show here that HPV16 E6 promotes the ubiquitination and degradation of E6AP itself. The half-life of E6AP is shorter in HPV-positive cervical cancer cells than in HPV-negative cervical cancer cells, and E6AP is stabilized in HPV-positive cancer cells when expression of the viral oncoproteins is repressed… CONTINUE READING
39 Citations
64 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 64 references

Similar Papers

Loading similar papers…