Human papillomavirus-related head and neck tumors: clinical and research implication

@article{Psyrri2009HumanPH,
  title={Human papillomavirus-related head and neck tumors: clinical and research implication},
  author={Amanda Psyrri and Panagiotis Gouveris and Jan Baptist Vermorken},
  journal={Current Opinion in Oncology},
  year={2009},
  volume={21},
  pages={201–205}
}
Purpose of review High-risk human papillomaviruses (HPVs) are implicated in the development of a subset of head and neck squamous cell cancers (HNSCCs), especially those arising from the lingual or palatine tonsils. HPV-associated HNSCCs represent a different disease entity from those associated with the traditional risk factors of tobacco and alcohol use. The demonstration that HPV is causally associated with a subset of HNSCC has tremendous clinical and research implications. Recent findings… 

Human papillomavirus in head and neck cancers: biology, prognosis, hope of treatment, and vaccines

This study summarizes the current knowledge regarding the epidemiology, biology, malignant transformation mechanisms, and prognosis of HPV-associated HNSCCs, and underlines the clinical implications of related treatments and prophylactic strategies.

The Role of Human Papillomavirus in Head and Neck Cancers

Investigations suggest that HPV infection in these anatomic sites is an independent risk factor for carcinogenesis, and the most frequently detected high-risk HPVs in HNSCC are the 16 and 18 genotypes.

Human Papilloma Virus in Head and Neck Squamous Cell Cancer

HPV infection has a significant impact on Head and Neck Squamous Cell Carcinomas, and despite HPV-16 stronger impact, HPV-18 is more likely to cause malignant degeneration in such cancers amongst some communities.

Human Papillomavirus: Changing Paradigms in Oropharyngeal Cancer

Patients with an HPV-associated oropharyngeal cancer have a distinctly better survival after treatment than those patients with HPV-negative tumors, although their prognosis is significantly worse if there is a history of tobacco abuse.

HPV status and overall survival of patients with oropharyngeal squamous cell carcinoma--a retrospective study of a German head and neck cancer center.

A prevalence of HPV-positive tumors within OSCC is confirmed, confirming its epidemiologic and prognostic relevance, and HPV status should be considered an important part of tumor staging.

Next‐generation treatment strategies for human papillomavirus‐related head and neck squamous cell carcinoma: where do we go?

Present therapeutic HPV‐targeting strategies are focused on, future directions for de‐intensified treatment of HPV‐positive HNSCC are discussed and the development and future use of new antiviral and immunomodulatory therapeutics are discussed.

Rethinking the head and neck cancer population: the human papillomavirus association.

  • C. Callaway
  • Medicine
    Clinical journal of oncology nursing
  • 2011
High-risk strains of the human papillomavirus (HPV) already are associated with cervical, oral, and anal cancers; however, HPV DNA has been detected in about a third of head and neck malignancies.
...

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