Human papillomavirus oncoproteins differentially modulate epithelial-mesenchymal transition in 5-FU-resistant cervical cancer cells

@article{Vishnoi2016HumanPO,
  title={Human papillomavirus oncoproteins differentially modulate epithelial-mesenchymal transition in 5-FU-resistant cervical cancer cells},
  author={Kanchan Vishnoi and Sutapa Mahata and Abhishek Tyagi and Arvind Pandey and Gaurav Verma and Mohit Jadli and Tejveer Singh and Sukh Mahendra Singh and Alok Chandra Bharti},
  journal={Tumor Biology},
  year={2016},
  volume={37},
  pages={13137-13154}
}
Etiological role of viral proteins E6 and E7 of high-risk HPV in cervical carcinogenesis is well established. However, their contribution in chemoresistance and epithelial-mesenchymal transition (EMT) that leads to advanced metastatic lesions and chemoresistance is poorly defined. In the present study, contribution of viral oncoproteins in acquisition of EMT character during onset of chemoresistance was assessed. A chemoresistant cell line (SiHaCR) was developed from an established HPV16… CONTINUE READING

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