Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

@article{Walboomers1999HumanPI,
  title={Human papillomavirus is a necessary cause of invasive cervical cancer worldwide},
  author={Jan M. M. Walboomers and Marcel V. Jacobs and M. Michele Manos and Francesc X. Bosch and Jean Alain Kummer and Keerti V. Shah and Peter J. F. Snijders and Julian Peto and Chris J.L.M. Meijer and Nubia Mu{\~n}oz},
  journal={The Journal of Pathology},
  year={1999},
  volume={189}
}
A recent report that 93 per cent of invasive cervical cancers worldwide contain human papillomavirus (HPV) may be an underestimate, due to sample inadequacy or integration events affecting the HPV L1 gene, which is the target of the polymerase chain reaction (PCR)‐based test which was used. The formerly HPV‐negative cases from this study have therefore been reanalysed for HPV serum antibodies and HPV DNA. Serology for HPV 16 VLPs, E6, and E7 antibodies was performed on 49 of the 66 cases which… 
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