Human papillomavirus infection is inhibited by host autophagy in primary human keratinocytes.

@article{Griffin2013HumanPI,
  title={Human papillomavirus infection is inhibited by host autophagy in primary human keratinocytes.},
  author={Laura M. Griffin and Louis Cicchini and Dohun Pyeon},
  journal={Virology},
  year={2013},
  volume={437 1},
  pages={12-9}
}
Human papillomavirus (HPV) infection is severely limited in its natural host, primary human keratinocytes. Our data show HPV infectivity in primary keratinocytes is over 100- and 1,000-fold lower than in established keratinocyte cell lines NIKS and HaCaT, respectively. Here, we show that the basal level of autophagy in primary human foreskin keratinocytes (HFKs) is higher than in immortalized keratinocytes, and that HPV16 virions significantly induce autophagy in HFKs. Interestingly, HPV16… CONTINUE READING
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