Human papillomavirus genotype as a major determinant of the course of cervical cancer.

@article{Lombard1998HumanPG,
  title={Human papillomavirus genotype as a major determinant of the course of cervical cancer.},
  author={I. Lombard and Anne Vincent-Salomon and Pierre Validire and Brigitte Zafrani and Anne de la Rochefordi{\`e}re and Krishna Clough and M. Favre and Pierre Pouillart and Xavier X Sastre-Garau},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1998},
  volume={16 8},
  pages={2613-9}
}
PURPOSE To determine whether the prognosis of invasive cancers of the uterine cervix is related to the type of human papillomavirus (HPV) associated with the tumor. PATIENTS AND METHODS Two hundred ninety-seven patients with invasive cervical cancer were prospectively registered from 1986 to 1994. HPV typing was performed on DNA extracted from frozen tumor specimens by means of Southern blot hybridization (SBH) and polymerase chain reaction (PCR) techniques. The median follow-up was 38 months… CONTINUE READING